Omecron 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.02 (4 x 10: ৳ 320.80)
Strip Price: ৳ 80.20

Medicine Details

Category Details
Generic Omeprazole
Company Nipro jmi pharma ltd
Also available as
Omecron 20 mg capsule

Indications

  • Treatment of gastric and duodenal ulcer
  • Treatment of NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Treatment of gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Treatment of acid-related dyspepsia
  • Treatment of severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Treatment of Zollinger-Ellison syndrome
  • Treatment of Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell
  • Onset of antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • Oral administration for various conditions and durations
  • Dosage ranges for different indications
  • Maintenance doses for recurrent duodenal ulcer and acid reflux disease
  • Pediatric dosing based on body weight
  • IV injection for prophylaxis of acid aspiration
  • IV injection for duodenal ulcer, gastric ulcer or reflux esophagitis
  • IV injection for Zollinger-Ellison syndrome
  • IV infusion directions

Administration

  • IV injection for intravenous administration only
  • IV infusion directions and precautions
  • Reconstitution and slow intravenous injection process
  • Preparation and time limits for solution use

Interaction

  • Potential interaction with ketoconazole
  • Metabolized in the liver through cytochrome P450
  • Possible delays in the elimination of diazepam, phenytoin, and warfarin
  • Monitoring and dose adjustments for patients receiving warfarin or phenytoin
  • Plasma concentration increase during concomitant administration with clarithromycin
  • Absorption unaffected by alcohol or food
  • No evidence of interaction with several drugs

Contraindications

  • Known hypersensitivity
  • Need to exclude malignancy before treatment if gastric ulcer is suspected

Side Effects

  • Mild and reversible adverse reactions
  • Reports of skin rash, urticaria, pruritus, photosensitivity, and bullous eruption
  • Gastrointestinal reactions including diarrhea, headache, constipation, and nausea/vomiting
  • Neurological symptoms such as paraesthesia, dizziness, and somnolence
  • Psychological effects including reversible mental confusion, agitation, and depression
  • Reports of arthritic and myalgic symptoms, blurred vision, and taste disturbance
  • Isolated cases of thrombocytopenia, agranulocytosis, and hepatotoxicity

Pregnancy & Lactation

  • No adverse effects on pregnancy or newborn child reported in epidemiological studies
  • Use during pregnancy deemed safe based on available information
  • No information on passage into breast milk or effects on neonate
  • Caution and possible discontinuation of breast-feeding if essential

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Observational studies suggesting increased risk for osteoporosis-related fractures
  • Noted occurrence of atrophic gastritis in patients treated long-term
  • Potential methotrexate toxicities with concomitant use

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Related Brands