Omeprol 40 mg/vial (IV Injection)

40 mg vial: ৳ 90.00

Medicine Details

Category	Details
Generic	Omeprazole
Company	Ziska pharmaceuticals ltd
Also available as	Omeprol 20 mg capsule Omeprol 40 mg capsule

Indications

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Acid-related dyspepsia
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

Pharmacology

Inhibitor of gastric acid secretion, onset of antisecretory effect within one hour, maximum effect within two hours, inhibition lasts up to 72 hours

Dosage

20 mg once daily for benign gastric and duodenal ulcer
40 mg once daily for prophylaxis of acid aspiration during general anesthesia
20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
10-20 mg daily for long-term management of acid reflux disease

Administration

IV Injection for prophylaxis of acid aspiration should be given slowly over a period of 5 minutes, IV infusion should be given over a period of 20-30 minutes or more

Interactions

Decreased intragastric acidity affecting absorption of ketoconazole
Metabolism through cytochrome P450 affecting drugs like diazepam, phenytoin, and warfarin
Increased plasma concentrations with clarithromycin during H. pylori eradication
No evidence of interaction with alcohol or food

Contraindications

Known hypersensitivity

Side Effects

Mild and reversible adverse reactions
Skin rash, urticaria, and pruritus reported
Diarrhea and headache in some cases
Gastrointestinal reactions including constipation, nausea, and flatulence
Dizziness, somnolence, insomnia, and vertigo reported
Reversible mental confusion, agitation, and depression in severely ill patients

Pregnancy & Lactation

Results from prospective epidemiological studies indicate no adverse effects on pregnancy or fetus/newborn child, breast-feeding discontinuation if use is essential

Precautions & Warnings

Avoid concomitant use of clopidogrel
Increased risk for osteoporosis-related fractures in observational studies
Atrophic gastritis noted occasionally in long-term use
Concomitant use with methotrexate may lead to toxicities

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat, keep out of the reach of children