Omidex 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (100's pack: ৳ 500.00)

Medicine Details

Category Details
Generic Omeprazole
Company Modern pharmaceuticals ltd

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasting up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 10-20 mg daily for long-term management of acid reflux disease
  • 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
  • 20 mg twice daily in association with antimicrobial agents for Helicobacter pylori eradication regimen
  • Intravenous injection for various conditions

Administration

  • IV Injection for prophylaxis and specific syndromes
  • IV Infusion over a period of 20-30 minutes or more

Interaction

  • Absorption of ketoconazole may be reduced during Omidex treatment
  • May delay the elimination of diazepam, phenytoin, and warfarin
  • Increased plasma concentrations during concomitant administration
  • No evidence of interaction with various drugs and substances

Contraindications

  • Known hypersensitivity to Omeprazole
  • Suspicion of gastric ulcer should exclude the possibility of malignancy before treatment

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhoea, headache, constipation, nausea/vomiting, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Dizziness, light headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Various isolated cases of adverse effects

Pregnancy & Lactation

  • No adverse effects on pregnancy or the health of the fetus/newborn child
  • Use during pregnancy indicated
  • No information available on the passage into breast milk or its effects on the neonate
  • Discontinue breast-feeding if essential use of Omeprazole is considered

Precautions & Warnings

  • Avoid concomitant use of clopidogrel
  • Increased risk for osteoporosis-related fractures
  • Occasional atrophic gastritis in gastric corpus biopsies from long-term treatment
  • Caution with concomitant use of PPIs with methotrexate

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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