Omitin 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (30's pack: ৳ 210.00)

Medicine Details

Category Details
Generic Omeprazole
Company Nipa pharmaceuticals ltd
Also available as
Omitin 20 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer for 4-8 weeks
  • 40 mg daily for severe or recurrent cases
  • 10-20 mg daily for long-term management of acid reflux disease
  • 20 mg once daily for gastro-esophageal reflux disease for 4-8 weeks
  • 40 mg once daily for refractory gastro-esophageal reflux disease
  • 20 mg twice daily for Helicobacter pylori eradication regimen
  • 10-20 mg once daily for acid-related dyspepsia for 2-4 weeks
  • 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
  • Initial 60 mg once daily for Zollinger-Ellison syndrome, with a usual range of 20-120 mg daily

Administration

  • IV Injection should be given slowly over a period of 5 minutes
  • IV Infusion should be given over a period of 20-30 minutes or more
  • Reconstituted solution for IV Infusion should not be mixed with any other drug

Interaction

  • Decreased intragastric acidity affecting the absorption of ketoconazole
  • Metabolized in the liver through cytochrome P450 system
  • Potential delay in the elimination of diazepam, phenytoin, and warfarin
  • Increased plasma concentrations during concomitant administration with clarithromycin
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, and others

Contraindications

  • Known hypersensitivity to omeprazole
  • Possible malignancy when gastric ulcer is suspected

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity and bullous eruption
  • Diarrhea and headache
  • Constipation, nausea/vomiting, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Dizziness, light-headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Mental confusion, agitation, and depression
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, and peripheral edema
  • Increased sweating and malaise
  • Hepatitis with or without jaundice, interstitial nephritis, and hepatic failure

Pregnancy & Lactation

  • No adverse effects of omeprazole on pregnancy or the health of the fetus/newborn child
  • Safety and effectiveness not established in pediatric patients less than 18 years of age

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Possible association with an increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in gastric corpus biopsies from long-term treatment
  • Potential methotrexate toxicities with concomitant use of PPIs

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat, and out of the reach of children

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