OP-40 40 mg/vial (IV Injection)

40 mg vial: ৳ 80.00

Medicine Details

Category Details
Generic Omeprazole
Company Globe pharmaceuticals ltd
Also available as
Op 20 20 mg capsule Op 40 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with history of NSAID-associated ulcers
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 40 mg daily for severe or recurrent cases
  • 10-20 mg daily for prevention of relapse in duodenal ulcer
  • 20 mg once daily for NSAID-associated duodenal or gastric ulcer
  • 20 mg once daily for prophylaxis in patients with a history of NSAID-associated ulcers
  • 20 mg once daily for gastro-esophageal reflux disease
  • 40 mg once daily for refractory gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on the preceding evening and 2-6 hours before surgery for prophylaxis of acid aspiration
  • Initially 60 mg once daily for Zollinger-Ellison syndrome
  • 20 mg twice daily with antimicrobial agents for Helicobacter pylori eradication regimen
  • 10-20 mg once daily for severe ulcerating reflux esophagitis in pediatric use
  • 40 mg intravenous injection for prophylaxis of acid aspiration
  • 40 mg intravenously once daily for duodenal ulcer, gastric ulcer, or reflux esophagitis IV injection
  • 60 mg initially for Zollinger-Ellison syndrome IV injection
  • 20-120 mg daily for Zollinger-Ellison syndrome IV injection

Administration

  • IV injection for intravenous administration only
  • IV infusion over a period of 20-30 minutes or more
  • Slow intravenous injection over a period of at least 2 to 5 minutes
  • Use only freshly prepared solution
  • Solution should be used within 4 hours of reconstitution
  • Solution should be used within 12 hours when dissolved in saline
  • Solution should be used within 6 hours when dissolved in 5% Dextrose
  • Reconstituted solution should not be mixed or co-administered with any other drug in the same infusion set

Interaction

  • Decreased intragastric acidity can reduce absorption of ketoconazole
  • Metabolized in the liver through cytochrome P450
  • Can delay the elimination of diazepam, phenytoin, and warfarin
  • Plasma concentrations of Omeprazole and clarithromycin are increased during concomitant administration
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, or antacids
  • Absorption is not affected by alcohol or food
  • No evidence of interaction with piroxicam, diclofenac, or naproxen
  • Simultaneous treatment with digoxin leads to a 10% increase in the bioavailability of digoxin

Contraindications

  • Known hypersensitivity to Omeprazole
  • Suspected gastric ulcer with possibility of malignancy

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Angioedema and alopecia
  • Diarrhea and headache
  • Constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Paraesthesia
  • Dizziness, light headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral edema, and increased sweating
  • Leucopenia, thrombocytopenia, agranulocytosis, and pancytopenia
  • Anaphylactic shock, malaise, and fever
  • Hepatitis with or without jaundice, interstitial nephritis, and hepatic failure
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child
  • Omeprazole can be used during pregnancy
  • Information not available on the passage into breast milk or effects on the neonate
  • Breastfeeding should be discontinued if essential
  • Safety and effectiveness not established in pediatric patients less than 18 years of age

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Omeprazole
  • PPI therapy may be associated with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in patients treated long-term
  • Concomitant use with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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