Probitor 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 10.10 (4 x 10: ৳ 404.00)

Strip Price: ৳ 101.00

Medicine Details

Category	Details
Generic	Omeprazole
Company	Sandoz a novartis division
Also available as	Probitor 20 mg capsule

Indications

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Long-term management of acid reflux disease
Acid-related dyspepsia
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

Pharmacology

Omeprazole, a substituted benzimidazole, is an inhibitor of gastric acid secretion. It inhibits gastric acid secretion by blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell. After oral administration, the onset of the antisecretory effect occurs within one hour, with the maximum effect occurring within two hours and inhibition of secretion lasts up to 72 hours. When the drug is discontinued, secretory activity returns gradually, over 3 to 5 days.

Dosage

Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration
NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks, continued for further 4 weeks if not fully healed
Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks, continued for further 4-8 weeks if not fully healed
Long-term management of acid reflux disease: 10-20 mg daily
Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks
Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery
Zollinger-Ellison syndrome: Initially 60 mg once daily; usual range 20-120 mg daily
Helicobacter pylori eradication regimen in peptic ulcer disease: Omeprazole is recommended at a dose of 20 mg twice daily in association with antimicrobial agents
Paediatric use in severe ulcerating reflux esophagitis (Child>1 year): If body-weight 10-20 kg, 10-20 -mg once daily for 4-12 weeks; if body-weight over 20 kg, 20-40 mg once daily for 4-12 weeks

Administration

Omeprazole IV injection should be given as a slow intravenous injection. The solution for IV injection is obtained by adding 10 ml water for injection to the vial containing powder. The IV infusion should be given over a period of 20-30 minutes or more.

Interaction

Probitor may interact with ketoconazole, diazepam, phenytoin, warfarin, clarithromycin, digoxin, and other drugs. It may also affect the absorption of certain medications.

Contraindications

Omeprazole is contraindicated in patients with known hypersensitivity to it. When gastric ulcer is suspected, the possibility of malignancy should be excluded before treatment.

Side Effects

Probitor is well tolerated, but adverse reactions may include skin rash, urticaria, pruritus, photosensitivity, diarrhoea, headache, constipation, nausea/vomiting, dizziness, etc.

Pregnancy & Lactation

Results from prospective epidemiological studies indicate no adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child. Omeprazole can be used during pregnancy, but its passage into breast milk and its effects on the neonate are unknown.

Precautions & Warnings

Avoid concomitant use of clopidogrel and Probitor, as it may reduce the pharmacological activity of clopidogrel. PPI therapy may be associated with an increased risk for osteoporosis-related fractures. Atrophic gastritis has been noted occasionally in patients treated long-term with Probitor.

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.