Alton 40 mg (Tablet (Enteric Coated))

Indications

• To relieve chronic heartburn symptoms and other symptoms associated with GERD
• For the healing of erosive esophagitis
• For the maintenance of healing of erosive esophagitis
• In combination with amoxicillin and clarithromycin for the eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
• For Zollinger-Ellison Syndrome
• For acid-related Dyspepsia
• For duodenal and gastric ulcers

Pharmacology

• Proton pump inhibitor
• Suppresses gastric acid secretion
• Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
• First single optical isomer of proton pump inhibitor
• Better acid control than racemic proton pump inhibitors
• Peak plasma levels occur at approximately 1.5 hours after oral administration
• Oral bioavailability is approximately 90%
• Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system
• Plasma elimination half-life is approximately 1-1.5 hours

Dosage

• Oral dosage form for various conditions
• IV Injection or IV infusion for GERD and risk reduction of rebleeding of gastric or duodenal ulcers
• Different doses for different age groups and conditions

Administration

• Tablet or capsule should be swallowed whole and taken one hour before a meal
• Oral suspension should be taken and administered with specific instructions
• IV Injection requires specific preparation and administration guidelines

Interaction

• Extensively metabolized in the liver by CYP2C19 and CYP3A4
• In vitro and in vivo studies show no clinically relevant interactions with specific CYP enzymes
• Potential interference with the absorption of drugs where gastric pH is important for bioavailability
• Increased plasma levels of certain drugs with co-administration

Contraindications

• Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

• Headache
• Diarrhea
• Nausea
• Flatulence
• Abdominal pain
• Constipation
• Dry mouth
• Similar adverse events in short-term and long-term treatment

Pregnancy & Lactation

• No adequate and well-controlled studies in pregnant women
• No teratogenic effects in animal studies
• Excretion in milk has not been studied, so breastfeeding should be discontinued if essential

Precautions & Warnings

• Symptomatic response does not rule out the presence of gastric malignancy
• Specific instructions for patients who have difficulty swallowing capsules
• Use of antacids while taking the medication

Use in Special Populations

• Safety and effectiveness not established in pediatric patients
• No overall differences in safety and efficacy observed in the elderly
• No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency

Overdose Effects

• Lethal dose in rats reported at a significantly higher level than the human dose
• Signs of acute toxicity include reduced motor activity, changes in respiratory frequency, tremor, and convulsions
• No specific antidote known, treatment should be symptomatic and supportive

Storage Conditions

• Store at a temperature not exceeding 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C17H19N3O3S
• Image of chemical structure provided

Common Questions about Alton 40 mg Tablet

• Information on the uses and working of the tablet
• Common side effects and their occurrence
• Safety during pregnancy and breastfeeding
• Onset of action and quick tips for consumption

Related Brands

• Alton 20 mg (Tablet (Enteric Coated)) - general-pharmaceuticals-ltd
• S-Ome 40 mg (Tablet (Enteric Coated)) - somatec-pharmaceuticals-ltd
• S-Ome 20 mg (Tablet (Enteric Coated)) - somatec-pharmaceuticals-ltd