Ema 40 mg/vial (IV Injection)

40 mg vial: ৳ 85.00

Medicine Details

Category Details
Generic Esomeprazole
Company Globe pharmaceuticals ltd
Also available as
Ema 20 mg tablet Ema 40 mg tablet Ema 20 mg capsule Ema 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal and Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • First single optical isomer of proton pump inhibitor
  • Enteric-coated pellet formulation
  • Metabolized in the liver by cytochrome P450 (CYP) enzyme system
  • Plasma protein binding
  • Plasma elimination half-life
  • Combination therapy with antimicrobials

Dosage

  • Oral dosage form
  • IV Injection or IV infusion
  • Specific dosage for different indications
  • Dosage for pediatric patients
  • Dosage for risk reduction of rebleeding of Gastric or Duodenal Ulcers following therapeutic endoscopy

Administration

  • Swallowed whole and taken one hour before a meal
  • Oral suspension administration
  • IV Injection administration

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Inhibition of CYP2C19
  • Potential interference with drug absorption
  • No clinically significant interactions with specific drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects in animal studies
  • Excretion of esomeprazole in milk not studied
  • Discontinuation of breastfeeding if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Instructions for patients with difficulty swallowing capsules
  • Use of antacids while taking Ema
  • Safety and effectiveness in pediatric and geriatric patients
  • No dosage adjustment for mild to moderate hepatic insufficiency
  • No alteration of pharmacokinetics in renal impairment

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No overall differences in safety and efficacy in elderly patients
  • No dosage adjustment for mild to moderate hepatic insufficiency
  • No alteration of pharmacokinetics in renal impairment

Overdose Effects

  • Signs of acute toxicity in animal studies
  • No specific antidote known
  • Symptomatic and supportive treatment recommended
  • Exclusion of multiple drug ingestion

Storage Conditions

  • Temperature not exceeding 30°C
  • Dry place
  • Protection from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image

Common Questions about Ema 40 mg/vial Injection

  • Use as a proton pump inhibitor
  • Treatment of gastroesophageal reflux disease (GERD)
  • Multiple uses including heartburn relief and ulcer treatment
  • Common side effects
  • Safety considerations for pregnant or breastfeeding individuals
  • Onset of action
  • Quick Tips for usage

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