Esocon 40 mg/vial (IV Injection)

40 mg vial: ৳ 65.00

Medicine Details

Category Details
Generic Esomeprazole
Company Biopharma limited
Also available as
Esocon 20 mg capsule Esocon 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Treatment of acid-related Dyspepsia
  • Treatment of Duodenal and Gastric ulcers

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Inhibition of H+/K+-ATPase
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation
  • Peak plasma levels at approximately 1.5 hours
  • Metabolized in the liver by CYP enzyme system
  • Extensive plasma protein binding
  • Systemic bioavailability of approximately 90%
  • 97% plasma protein binding
  • Plasma elimination half-life of approximately 1-1.5 hours

Dosage

  • Oral dosage form
  • 20 mg or 40 mg Once Daily for 4-8 Weeks for healing of erosive esophagitis
  • 20 mg Once Daily for maintenance of healing of erosive esophagitis
  • 20 mg Once Daily for symptomatic GERD
  • Triple Therapy for Helicobacter pylori eradication
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for acid-related Dyspepsia
  • 20 mg once daily for 2-4 weeks for Duodenal ulcer
  • 20-40 mg once daily for 4-8 weeks for Gastric ulcer
  • IV Injection or infusion for specific conditions and age groups

Administration

  • Swallow whole and take one hour before a meal for tablet or capsule
  • Specific instructions for oral suspension
  • Preparation of IV injection solution
  • Specific administration times and conditions

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Inhibition of gastric acid secretion
  • Possible interference with CYP2C19 and CYP3A4 substrates
  • Potential drug interaction with oral contraceptives, diazepam, phenytoin, or quinidine
  • Interactions with clarithromycin and amoxicillin

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects in animal studies
  • Excretion of esomeprazole in milk not studied

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Specific instructions for patients with difficulty swallowing capsules

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No overall differences in safety and efficacy in geriatric use
  • No dosage adjustment for patients with mild to moderate hepatic insufficiency
  • Expected unaltered pharmacokinetics in patients with renal impairment

Overdose Effects

  • Lethal effects observed in animal studies for high doses

Storage Conditions

  • Temperature not exceeding 30°C
  • Protection from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions about Esocon 40 mg/vial Injection

  • General overview of Esocon 40 mg/vial Injection
  • Multiple uses of Esocon 40 mg/vial Injection
  • Common side effects of Esocon 40 mg/vial Injection
  • Considerations for pregnancy and breastfeeding
  • Duration for Esocon 40 mg/vial Injection to work
  • Quick tips for taking Esocon 40 mg/vial Injection

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