Esomo 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 6.02 (6 x 10: ৳ 361.20)
Strip Price: ৳ 60.20

Medicine Details

Category Details
Generic Esomeprazole
Company Amulet pharmaceuticals ltd
Also available as
Esomo 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal and Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • First single optical isomer of proton pump inhibitor
  • Enteric-coated pellet formulation of esomeprazole magnesium
  • Gastric acid suppression
  • Metabolized in the liver by cytochrome P450 (CYP) enzyme system
  • Plasma elimination half-life of approximately 1-1.5 hours
  • High plasma protein binding (97%)
  • Extensive metabolism in the liver
  • Minimal excretion in urine

Dosage

  • Oral dosage form
  • Healing of erosive esophagitis: 20mg or 40mg once daily for 4-8 weeks
  • Symptomatic GERD: 20mg once daily for 4 weeks
  • Helicobacter pylori eradication: Esomeprazole 40mg once daily for 10 days
  • IV Injection: 20mg or 40mg once daily for adult patients
  • Pediatric patients dosage based on body weight
  • Dosage adjustment for risk reduction of rebleeding of gastric or duodenal ulcers

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral suspension should be taken with water and within a specific time frame
  • IV Injection solution for injection preparation and administration instructions

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Potential interference with absorption of certain drugs
  • No clinically significant interactions with specific drugs
  • Inhibition of gastric acid secretion

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies show no teratogenic effects
  • Excretion of esomeprazole in milk not studied
  • Breastfeeding discontinuation if essential use of esomeprazole

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Instructions for patients with difficulty swallowing capsules
  • Use of antacids while taking esomeprazole

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No overall differences in safety and efficacy observed in the elderly
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Lethal effects observed in animal studies at high doses
  • Symptomatic and supportive treatment recommended in case of overdose

Storage Conditions

  • Temperature not exceeding 30°C
  • Dry place
  • Protection from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image: URL to image of chemical structure

Common Questions about Esomo 20 mg Capsule

  • Usage: Proton pump inhibitor for treating various conditions related to stomach acid
  • Side Effects: Headache, diarrhea, nausea, flatulence, abdominal pain, constipation, dry mouth
  • Pregnancy & Breastfeeding: Consult a doctor for risk assessment
  • Onset of Action: Usually starts working within a few hours

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