Esomo 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.03 (5 x 6: ৳ 240.90)
Strip Price: ৳ 48.18

Medicine Details

Category Details
Generic Esomeprazole
Company Amulet pharmaceuticals ltd
Also available as
Esomo 20 mg capsule

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid related Dyspepsia
  • Treatment of duodenal and gastric ulcers

Pharmacology

  • Mode of Action: Proton pump inhibitor that suppresses gastric acid secretion
  • Absorption: Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Distribution: 97% bound to plasma proteins
  • Metabolism: Extensively metabolized in the liver by the cytochrome P450 enzyme system
  • Excretion: Plasma elimination half-life is approximately 1–1.5 hours

Dosage

  • Oral Dosage Form:
    • Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
    • Symptomatic GERD: 20 mg Once Daily for 4 Weeks
    • Helicobacter Pylori Eradication: Triple Therapy with Esomeprazole 40 mg Once Daily for 10 days
  • IV Injection or IV Infusion: Dosage varies for adult and pediatric patients

Administration

  • Tablet or Capsule: Should be swallowed whole and taken one hour before a meal
  • Oral Suspension: Should be taken with water and consumed within 30 minutes
  • IV Injection: Must be administrated intravenously over a period of at least 3 minutes

Interaction

  • Metabolism: Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Inhibition: Potential interference with the absorption of drugs where gastric pH is essential for bioavailability

Contraindications

Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal Pain
  • Constipation
  • Dry Mouth

Pregnancy & Lactation

No adequate and well-controlled studies in pregnant women, excretion in milk not studied

Precautions & Warnings

Symptomatic response to therapy does not preclude the presence of gastric malignancy

Use in Special Populations

  • No established safety and effectiveness in pediatric patients
  • No overall differences in safety and efficacy observed between the elderly and younger individuals

Overdose Effects

Lethal dose in rats, may cause reduced motor activity, respiratory changes, tremor, and convulsions

Storage Conditions

Store at a temperature not exceeding 30°C in a dry place, protect from light and moisture

Chemical Structure

Molecular Formula: C17H19N3O3S, Chemical Structure image available

Commonly Asked Questions

  • Uses of Esomeprazole
  • Side Effects
  • Pregnancy & Breastfeeding
  • Onset of Action

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