Esoprex 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 11.00 (3 x 10: ৳ 330.00)
Strip Price: ৳ 110.00

Medicine Details

Category Details
Generic Esomeprazole
Company Beacon pharmaceuticals plc
Also available as
Esoprex 20 mg capsule Esoprex 40 mg injection

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • Better acid control than racemic proton pump inhibitors
  • Absorption: Enteric-coated pellet formulation
  • Peak plasma levels at approximately 1.5 hours
  • Distribution: 97% bound to plasma proteins
  • Metabolism: Extensively metabolized in the liver
  • Excretion: Less than 1% excreted in the urine

Dosage

  • Oral dosage form
  • IV Injection or IV infusion
  • Dosage range for different indications

Administration

  • Tablet or capsule: Swallowed whole, taken one hour before a meal
  • Oral Suspension: Preparation and administration
  • IV Injection: Preparation and administration

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Inhibition of CYP2C19
  • Interference with drug absorption based on gastric pH

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Excretion in milk not studied
  • Breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Instructions for patients regarding capsule administration

Use in Special Populations

  • Paediatric Use: Safety and effectiveness not established
  • Geriatric Use: No overall differences in safety and efficacy observed
  • Hepatic Insufficiency: Dosage adjustment recommendation
  • Renal Insufficiency: Pharmacokinetics not expected to be altered

Overdose Effects

  • Lethal dose observed in rats
  • Signs of acute toxicity
  • No reports of overdose in humans

Storage Conditions

  • Temperature not exceeding 30°C
  • Dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: Image available

Common Questions about Esoprex 40 mg Capsule

  • Description of medication's action
  • Uses of the medication
  • Common side effects
  • Use during pregnancy and breastfeeding
  • Onset of action and quick tips for usage

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