EZ-20 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (5 x 10: ৳ 350.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Modern pharmaceuticals ltd

Product Title

  • EZ-20 20 mg Capsule

Categories

  • Heartburn Relief
  • Gastroesophageal Reflux Disease (GERD) Treatment
  • Erosive Esophagitis Healing
  • Helicobacter pylori Infection Eradication
  • Zollinger-Ellison Syndrome Management
  • Acid-related Dyspepsia Relief
  • Duodenal and Gastric Ulcer Treatment

Description

  • Proton Pump Inhibitor
  • First Single Optical Isomer of Proton Pump Inhibitor
  • Suppresses Gastric Acid Secretion
  • Relief from Chronic Heartburn Symptoms
  • Treatment for Symptomatic GERD
  • Prevents Erosive Esophagitis Recurrence
  • Oral and IV Dosage Forms
  • Extensively Metabolized in the Liver
  • Storage Temperature Not Exceeding 30°C
  • Molecular Formula: C17H19N3O3S

Color Options

  • No specific color options

Function

  • Relief from heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Management of Zollinger-Ellison Syndrome
  • Treatment for acid-related dyspepsia
  • Treatment for duodenal and gastric ulcers

Dosage

  • 20 mg or 40 mg Once Daily for 4-8 Weeks
  • 20 mg Once Daily for maintenance
  • Relief from Symptomatic GERD: 20 mg Once Daily for 4 Weeks
  • Triple Therapy: Esomeprazole 40 mg Once Daily for 10 days, Amoxicillin 1000 mg Twice Daily for 10 days, Clarithromycin 500 mg Twice Daily for 10 days
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for 2-4 weeks for acid-related dyspepsia
  • 20 mg once daily for 2-4 weeks for duodenal ulcer, 20-40 mg once daily for 4-8 weeks for gastric ulcer
  • IV Dosage for GERD with Erosive Esophagitis: 20 mg or 40 mg once daily
  • Pediatric IV Dosage from 10 mg to 20 mg depending on body weight
  • IV Dosage for Risk reduction of rebleeding of Gastric or Duodenal Ulcers: 80 mg IV Infusion followed by a continuous infusion of 8 mg/h for 72 hours

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension should be taken into a small glass containing 15 ml of water, stirred well and drunk within 30 minutes
  • IV Injection solution prepared by adding 5 ml of 0.9% Sodium Chloride for intravenous injection into the vial containing the dry powder, and must be administrated intravenously over a period of at least 3 minutes

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal and Gastric Ulcer

Pharmacology

  • Suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase
  • Provides better acid control than racemic proton pump inhibitors
  • Absorption occurs at approximately 1.5 hours after oral administration
  • Esomeprazole capsules contain an enteric-coated pellet formulation of esomeprazole magnesium

Mode of Action

  • Inhibits the H+/K+-ATPase in the gastric parietal cell
  • Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Metabolites lack anti-secretory activity

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
  • No clinically relevant interactions with drugs metabolized by these CYP enzymes
  • May interfere with the absorption of drugs where gastric pH is important for bioavailability

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth
  • No difference in types of related adverse events observed during maintenance treatment up to 12 months compared to short-term treatment

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Capsules should be taken at least one hour before meals
  • Antacids may be used while taking the medication

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies have revealed no teratogenic effects
  • The excretion of esomeprazole in milk has not been studied
  • Breast-feeding should be discontinued if the use of esomeprazole is considered essential

Use in Special Populations

  • Safety and effectiveness in pediatric patients have not been established
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • Greater sensitivity of some older individuals cannot be ruled out
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • No dosage adjustment recommended for patients with renal impairment

Overdose Effects

  • A single oral dose of 510 mg/kg has been lethal to rats
  • No specific antidote for overdose is known
  • Treatment should be symptomatic and supportive
  • The possibility of multiple drug ingestion should be considered

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure available (refer to the link provided)

Related Brands