NexCap 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole
Company Unimed unihealth pharmaceuticals ltd
Also available as
Nexcap 20 mg capsule

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Inhibition of the H+/K+-ATPase in the gastric parietal cell
  • Enteric-coated pellet formulation
  • Peak plasma levels occur at approximately 1.5 hours
  • Systemic bioavailability is approximately 90%
  • Extensively metabolized in the liver
  • CYP2C19 and CYP3A4 dependent metabolism
  • Plasma elimination half-life is approximately 1–1.5 hours

Dosage

  • Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
  • Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily
  • Symptomatic GERD: 20 mg Once Daily for 4 Weeks
  • Helicobacter Pylori eradication: Triple Therapy for 10 days
  • Zollinger-Ellison Syndrome: 20-80 mg once daily
  • Acid-related Dyspepsia: 20-40 mg once daily for 2-4 weeks
  • Duodenal ulcer: 20 mg once daily for 2-4 weeks
  • Gastric ulcer: 20-40 mg once daily for 4-8 weeks
  • IV Injection: 20 mg or 40 mg once daily, with specific administration times for different age groups and conditions

Administration

  • Tablet or capsule: Swallowed whole and taken one hour before a meal
  • Oral Suspension: Should be taken with water and administered through a nasogastric or gastric tube if necessary
  • IV Injection: Must be administered intravenously over a period of at least 3 minutes

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Not likely to inhibit specific CYP enzymes
  • May potentially interfere with CYP2C19
  • Inhibits gastric acid secretion, potentially interfering with the absorption of other drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies have revealed no teratogenic effects
  • Excretion in milk not studied, breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • NexCap capsules should be taken at least one hour before meals
  • Use with caution for patients who have difficulty swallowing capsules

Use in Special Populations

  • Paediatric Use: Safety and effectiveness not established
  • Geriatric Use: No overall differences in safety and efficacy observed
  • Hepatic Insufficiency: No dosage adjustment for mild to moderate hepatic insufficiency
  • Renal Insufficiency: Pharmacokinetics not expected to be altered

Overdose Effects

  • Lethal to rats at high doses
  • Reduced motor activity, changes in respiratory frequency, tremor, ataxia, and intermittent clonic convulsions

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions about NexCap 40 mg Capsule

  • Multiple uses including treating heartburn, GERD, ulcers, and preventing erosive esophagitis recurrence
  • Common side effects include headaches, diarrhea, nausea, and more
  • No adverse effects on pregnancy or breastfeeding reported
  • Rapid onset of action within a few hours

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