Prevas 40 mg/vial (IV Injection)

40 mg vial: ৳ 80.00

Medicine Details

Category Details
Generic Omeprazole
Company General pharmaceuticals ltd
Also available as
Prevas 20 mg capsule Prevas 40 mg capsule

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer treatment
  • Prophylaxis for patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease treatment
  • Long-term management of acid reflux disease
  • Treatment of acid-related dyspepsia
  • Treatment of severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Treatment of Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer treatment

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasting up to 72 hours
  • Return of secretory activity gradually over 3 to 5 days after discontinuation

Dosage

  • Dosage for benign gastric and duodenal ulcer
  • Dosage for NSAID-associated duodenal or gastric ulcer
  • Dosage for gastro-esophageal reflux disease
  • Dosage for long-term management of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Dosage for Helicobacter pylori eradication regimen in peptic ulcer disease
  • Pediatric use in severe ulcerating reflux esophagitis

Administration

  • Directions for use of IV Injection
  • Directions for use of IV Infusion
  • Reconstitution of IV Injection
  • Reconstitution of IV Infusion
  • Duration of IV Infusion
  • Preparation of IV Infusion solution

Interaction

  • Effect on ketoconazole absorption
  • Metabolism through cytochrome P450
  • Potential interaction with diazepam, phenytoin, and warfarin
  • Monitoring recommendation for patients receiving warfarin or phenytoin
  • Plasma concentration changes during concomitant administration

Contraindications

  • Known hypersensitivity to omeprazole
  • Need for excluding malignancy before treatment in suspected gastric ulcer cases

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, erythema multiforme
  • Gastrointestinal reactions
  • Headache and diarrhea
  • Symptoms requiring discontinuation of therapy
  • Neurological reactions
  • Liver enzyme observation

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child in epidemiological studies
  • Safe use during pregnancy
  • No information on passage into breast milk or effects on the neonate
  • Discontinuation of breast-feeding if essential

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Prevas
  • Possible risk of osteoporosis-related fractures with PPI therapy
  • Atrophic gastritis noted in long-term treatment
  • Potential methotrexate toxicities with PPIs

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place
  • Away from light and heat
  • Keep out of the reach of children

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