Amlosin Plus 5 mg+25 mg (Tablet)

Unit Price: ৳ 4.00 (30's pack: ৳ 120.00)

Medicine Details

Category Details
Generic Amlodipine besilate atenolol
Company Doctors chemical works ltd

Indications

  • Patients with essential hypertension
  • Patients with angina pectoris & hypertension as co-existing diseases
  • ln post Ml patients
  • ln patients with refractory angina pectoris where nitrate therapy has failed.

Pharmacology

  • Fixed-dose combination of Amlodipine and Atenolol
  • Amlodipine is a dihydropyridine calcium antagonist
  • Amlodipine reduces tone and decreases coronary vasoreactivity
  • Atenolol is a cardioselective beta-blocker
  • Atenolol causes a reduction in blood pressure by lowering cardiac output

Dosage & Administration

Recommended dosage is Amlodipine and Atenolol 5/25 mg tablet once daily. Dosage may be increased as advised by physicians.

Interactions

  • Atenolol reduces the clearance of disopyramide
  • Ampicillin may reduce Atenolol levels
  • Beta-blockers may decrease tissue sensitivity to insulin and inhibit insulin secretion

Contraindications

  • Hypersensitivity to either component
  • Sinus bradycardia
  • Second and higher degrees of heart block
  • Cardiogenic shock
  • Hypotension
  • Congestive heart failure
  • Poor left ventricular function

Side Effects

  • Fatigue
  • Headache
  • Edema
  • Nausea
  • Drowsiness
  • Anxiety
  • Depression

Pregnancy & Lactation

Should be used during pregnancy only if expected benefit outweighs potential fetal risk. Should not be used by nursing mothers. If its use is considered necessary, breastfeeding should be stopped.

Precautions & Warnings

  • Use with caution in patients with airway obstruction
  • Can be used in patients with renal impairment
  • Caution necessary if creatinine clearance is less than 30 ml/min
  • Caution necessary in the use of the combination in patients with severe liver damage
  • Patients should be warned against stopping the drug suddenly

Overdose Effects

Hypotension and less frequently congestive cardiac failure may occur in cases of overdosage. Unabsorbed drugs may be removed by gastric lavage or administration of activated charcoal. Symptomatic treatment is suggested.

Therapeutic Class

Combined antihypertensive preparations

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

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