Tyclav BID (400 mg+57.50 mg)/5 ml (Powder for Suspension)

50 ml bottle: ৳ 230.00

Medicine Details

Category Details
Generic Amoxicillin clavulanic acid
Company Beximco pharmaceuticals ltd
Also available as
Tyclav 125 mg suspension Tyclav 500 mg injection Tyclav 1 gm injection Tyclav 875 mg tablet Tyclav 250 mg tablet Tyclav 500 mg tablet

Product Title

  • Co-amoxiclav

Category

  • Medicine
  • Antibiotic

Indications

  • Treatment of bacterial infections in upper respiratory tract, lower respiratory tract, genito-urinary tract, skin and soft tissue, bone and joint, and other infections

Composition

  • 375 mg tablet
  • 625 mg tablet
  • 1 gm tablet
  • Powder for Suspension
  • Powder for Suspension (Forte)
  • 1.2 gm Injection
  • 0.6 gm injection

Active Ingredients

  • Amoxicillin Trihydrate BP
  • Clavulanic Acid
  • Diluted Potassium Clavulanate BP
  • Amoxicillin Sodium BP
  • Clavulanate Potassium USP

Pharmacology

  • Bactericidal activity against Gram-positive & Gram-negative microorganisms
  • Protection of Amoxicillin from degradation by (3-lactamase enzymes
  • Peak serum levels occur about one hour after oral administration

Dosage

  • Adjusted dosages for adults, children over 12 years and children of different age groups
  • Different dosages for different types of infections
  • IV Injection dosage for adults and children

Administration

  • Oral dosage form can be taken with or without meals
  • IV injection is not suitable for intramuscular or subcutaneous administration
  • Reconstituted vial must be used within 20 minutes

Interaction

  • Prolongation of bleeding time and prothrombin time reported in some patients
  • Possible reduction of efficacy of oral contraceptives
  • Concomitant use with allopurinol and allergic skin reactions

Contraindications

  • History of Penicillin hypersensitivity
  • Possible cross-sensitivity with other beta-lactam antibiotics
  • Contraindicated for patients with previous Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side Effects

  • Uncommon and mainly of mild and transitory nature
  • Gastrointestinal side effects may be reduced by taking with meals
  • Rare reports of hepatitis, cholestatic jaundice, rashes, angioedema and anaphylaxis

Pregnancy & Lactation

  • Animal studies show no teratogenic effect
  • Limited use in human pregnancy with no untoward effect
  • Use in lactation results in trace quantities of Amoxicillin in breast milk

Precautions & Warnings

  • Use with care in patients on anticoagulation therapy or with severe hepatic dysfunction
  • Dosage adjustment in case of moderate or severe renal impairment
  • Maintain adequate fluid intake and urinary output during high dose administration

Use in Special Populations

  • Dosage adjustment in case of patients with renal impairment
  • Administration hepatic impairment with caution; monitor hepatic function at regular intervals

Overdose Effects

  • Unlikely problems of overdose
  • Possible gastrointestinal symptoms and disturbance of fluid and electrolyte balances
  • Possible removal from circulation by haemodialysis

Therapeutic Class

  • Broad spectrum penicillins

Reconstitution

  • IV injection reconstitution with Water for Injection BP

Storage Conditions

  • Store below 25°C, protected from light and moisture
  • Reconstituted suspension should be kept in the refrigerator (but not frozen)
  • Reconstituted vial must be used within 20 minutes

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