Acmecilin 250 mg (Capsule)
Unit Price: ৳ 3.34 (10 x 10: ৳ 334.00)
Strip Price: ৳ 33.40
Medicine Details
| Category | Details |
|---|---|
| Generic | Ampicillin sodium |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Treatment of infections of the genitourinary tract including gonorrhea
- Infections of the respiratory tract
- Meningitis
- Bacteriology studies to determine causative organisms
- Results of susceptibility testing
- Therapy institution prior to susceptibility testing results
Pharmacology
- Inhibition of bacterial cell wall synthesis
- Binding to penicillin-binding proteins
- Inhibition of the final transpeptidation step of peptidoglycan synthesis
- Lysis of bacteria
- Activity of cell wall autolytic enzymes
Dosage
- Dosage for intra-articular administration
- Dosage for intraperitoneal administration
- Dosage for intrapleural administration
- Dosage for intravenous administration in meningitis
- Dosage for intrapartum prophylaxis
- Dosage for oral administration in various infections
- Dosage for parenteral administration in susceptible infections
- Dosage for septicaemia
Administration
- Take on an empty stomach
- Take 1 hour before or 2 hours after meals
Interaction
- Reduction of oral contraceptives efficacy
- Alteration of INR during warfarin and phenindione use
- Reduction of oral typhoid vaccines efficacy
- Reduced excretion with probenecid and sulfinpyrazone
- Increased risk of toxicity with reduced excretion
- Allopurinol's effect on ampicillin-induced skin reactions
- Reduced absorption with chloroquine
- Interference with bactericidal action by bacteriostatic antibacterials
Contraindications
- Hypersensitivity to ampicillin and other penicillins
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Rashes
- Sore mouth
- Rash
- Fever
- Joint pains
- Haemolytic anaemia
- Thrombocytopenia
- Leucopenia
- Neutropenia
- CNS toxicity
- Paraesthesia
- Nephropathy
- Interstitial nephritis
- Hepatitis
- Cholestatic jaundice
- Increased transaminases
- Anaphylaxis
Pregnancy & Lactation
- Pregnancy category B
- Animal-reproduction studies
- Adverse effects in animal-reproduction studies
- Decrease in fertility
Precautions & Warnings
- Beta-lactam allergy history
- Renal impairment precautions during pregnancy and lactation
Use in Special Populations
- Renal impairment - CrCl<10: Dose reduction or increase in dose interval
Overdose Effects
- Symptoms of overdose - nausea, vomiting, diarrhea
- Management of overdose - symptomatic and supportive treatment, potential use of haemodialysis
Reconstitution
- Reconstitution for intramuscular administration
- Reconstitution for intravenous administration
- Reconstitution for intra-articular administration
- Reconstitution for intraperitoneal administration
- Reconstitution for intrapleural administration
Storage Conditions
- Storage temperature between 20-25°C
- Reconstituted oral suspension storage temperature between 2-8°C, discard after 14 days