Omag-DR 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 3.00 (10 x 10: ৳ 300.00)
Strip Price: ৳ 30.00

Medicine Details

Category Details
Generic Omeprazole
Company Rangs pharmaceuticals ltd
Also available as
Prevencid 20 mg capsule Prevencid 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect occurs within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 10-20 mg daily for long-term management of acid reflux disease
  • 40 mg for prophylaxis of acid aspiration
  • 60 mg once daily for Zollinger-Ellison syndrome
  • 20 mg twice daily for Helicobacter pylori eradication regimen
  • 10-40 mg once daily for severe ulcerating reflux esophagitis

Administration

  • IV injection for prophylaxis of acid aspiration
  • IV infusion over a period of 20-30 minutes or more

Interaction

  • Decreased intragastric acidity affecting the absorption of ketoconazole
  • Metabolism through cytochrome P450 delaying the elimination of diazepam, phenytoin, and warfarin
  • Plasma concentrations of Omag-DR and clarithromycin increased during concomitant administration
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, or antacids

Contraindications

  • Known hypersensitivity to Omeprazole
  • Suspected gastric ulcer with possibility of malignancy

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhoea and headache
  • Constipation, nausea/vomiting, and flatulence
  • Dizziness, light-headedness, and feeling faint
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects of Omeprazole on pregnancy or fetus/newborn child
  • Use during pregnancy is indicated
  • No information available on the passage of Omeprazole into breast milk or its effects on the neonate

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Omag-DR
  • Increased risk for osteoporosis-related fractures with PPI therapy
  • Atrophic gastritis noted occasionally in long-term treatment
  • Concomitant use of PPIs with methotrexate may lead to toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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