Omet 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 3.50 (60's pack: ৳ 210.00)

Medicine Details

Category Details
Generic Omeprazole
Company Pharmadesh laboratories ltd

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer treatment
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease treatment
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia treatment
  • Severe ulcerating reflux esophagitis treatment
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome treatment
  • Helicobacter pylori-induced peptic ulcer treatment

Pharmacology

  • Omeprazole
  • Substituted benzimidazole
  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days

Dosage

  • Dosage for benign gastric and duodenal ulcer
  • Dosage for NSAID-associated duodenal or gastric ulcer
  • Dosage for gastro-esophageal reflux disease
  • Dosage for long-term management of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Dosage for Helicobacter pylori eradication regimen in peptic ulcer disease
  • Pediatric use in severe ulcerating reflux esophagitis (Child>1 year)
  • Oral administration
  • IV Injection administration

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion
  • For intravenous administration only
  • IV injection should be given as a slow intravenous injection
  • IV infusion should be given over a period of 20-30 minutes or more

Interaction

  • Decreased intragastric acidity affecting absorption of ketoconazole
  • Metabolism through cytochrome P450 affecting diazepam, phenytoin, and warfarin
  • Plasma concentrations of Omeprazole and clarithromycin are increased during concomitant administration
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxicillin, or antacids
  • No effect of alcohol or food on Omeprazole absorption
  • Increased bioavailability of digoxin during simultaneous treatment with Omeprazole

Contraindications

  • Known hypersensitivity to Omeprazole
  • Suspected gastric ulcer with possibility of malignancy

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
  • Diarrhea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Paraesthesia
  • Dizziness, light headedness, feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral edema, increased sweating, gynaecomastia
  • Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock
  • Malaise, fever, bronchospasm, encephalopathy, hepatitis, interstitial nephritis, hepatic failure
  • Increases in liver enzymes

Pregnancy & Lactation

  • Safety in pregnancy
  • No adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child
  • No information available on the passage of Omeprazole into breast milk or its effects on the neonate
  • Breastfeeding should be discontinued if the use of Omeprazole is considered essential
  • Use not established in pediatric patients less than 18 years of age

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Omeprazole
  • Increased risk for osteoporosis-related fractures with PPI therapy
  • Atrophic gastritis noted occasionally in gastric corpus biopsies from long-term Omeprazole treatment
  • Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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