PPI 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 9.00 (4 x 10: ৳ 360.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Omeprazole
Company Acme laboratories ltd
Also available as
Ppi 20 mg capsule Ppi 40 mg injection

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • Oral administration for various conditions
  • Doses ranging from 10mg to 120mg depending on the condition
  • Specific regimens for pediatric use
  • Intravenous administration for prophylaxis of acid aspiration and other conditions

Administration

  • Directions for use of IV Injection
  • Directions for use of IV Infusion
  • Preparation and reconstitution instructions
  • IV administration guidelines

Interaction

  • Potential interaction with ketoconazole affecting absorption
  • Metabolism through cytochrome P450 affecting drugs like diazepam, phenytoin, and warfarin
  • Monitoring and potential dose adjustment for concomitant use with warfarin or phenytoin
  • Plasma concentration changes during concurrent administration
  • No evidence of interaction with certain drugs and substances

Contraindications

  • Known hypersensitivity to omeprazole
  • Exclusion of malignancy before treatment

Side Effects

  • Well-tolerated with generally mild and reversible adverse reactions
  • Reports of skin reactions, gastrointestinal symptoms, and neurological effects
  • Rare reports of hepatic and hematological adverse events

Pregnancy & Lactation

  • Results from epidemiological studies indicating no adverse effects on pregnancy
  • No information available on passage into breast milk and effects on neonate
  • Recommendation to discontinue breastfeeding if essential

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Observational association with increased risk for osteoporosis-related fractures
  • Potential development of atrophic gastritis with long-term use
  • Potential interaction with methotrexate leading to toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Dry place away from light and heat
  • Keep out of the reach of children

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