Xeldrin 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 6.00 (10 x 10: ৳ 600.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Omeprazole
Company Aci limited
Also available as
Xeldrin 10 mg capsule Xeldrin 40 mg capsule Xeldrin 40 mg injection

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

Inhibits gastric acid secretion by blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell.

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer for 4 weeks in duodenal ulceration
  • 20 mg once daily for 4 weeks for NSAID-associated duodenal or gastric ulcer
  • 20 mg once daily for 4 weeks for gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for 2-4 weeks for acid-related dyspepsia
  • 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
  • Initially 60 mg once daily for Zollinger-Ellison syndrome
  • 20 mg twice daily with antimicrobial agents for Helicobacter pylori eradication regimen

Administration

Intravenous administration recommended for some specific indications. Oral and IV administration details provided.

Interaction

Potential interactions with ketoconazole, diazepam, phenytoin, warfarin, clarithromycin, amoxicillin, metronidazole, and more.

Contraindications

Contraindicated in patients with known hypersensitivity to omeprazole.

Side Effects

  • Mild and reversible adverse reactions reported
  • Skin rash, urticaria, and pruritus
  • Diarrhea, headache, constipation, nausea/vomiting
  • Dry mouth, stomatitis, candidiasis
  • Dizziness, light headedness, feeling faint
  • Paraesthesia, somnolence, insomnia, vertigo
  • Reversible mental confusion, agitation, depression, hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral edema
  • Increased sweating, gynaecomastia, leucopenia, thrombocytopenia

Pregnancy & Lactation

Omeprazole can be used during pregnancy, breastfeeding should be discontinued if essential.

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Observational studies suggest increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in gastric corpus biopsies
  • Concomitant use with methotrexate may lead to toxicities

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat, out of the reach of children

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