Xeldrin 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 9.00 (5 x 8: ৳ 360.00)
Strip Price: ৳ 72.00

Medicine Details

Category Details
Generic Omeprazole
Company Aci limited
Also available as
Xeldrin 10 mg capsule Xeldrin 20 mg capsule Xeldrin 40 mg injection

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H⁺/K⁺ ATPase) enzyme system
  • Onset of the antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 40 mg daily in severe or recurrent cases of gastric ulcer
  • 10-20 mg daily for prevention of relapse in duodenal ulcer
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
  • 20-120 mg daily for Zollinger-Ellison syndrome

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion
  • Intravenous administration only
  • Reconstitution and slow injection guidelines

Interaction

  • Decreased intragastric acidity affecting ketoconazole absorption
  • Metabolism through cytochrome P450 affecting diazepam, phenytoin, and warfarin elimination
  • Plasma concentrations affected during concomitant administration with clarithromycin
  • Increase in bioavailability of digoxin during simultaneous treatment

Contraindications

  • Known hypersensitivity to Omeprazole
  • Suspected gastric ulcer with possibility of malignancy

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhoea, headache, constipation, and nausea/vomiting
  • Dry mouth, stomatitis, and candidiasis
  • Paraesthesia, dizziness, and feeling faint
  • Reports of reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child
  • No information available on passage into breast milk
  • Discontinuation of breastfeeding if essential use is considered

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Increased risk for osteoporosis-related fractures with proton pump inhibitor (PPI) therapy
  • Atrophic gastritis noted occasionally with long-term use
  • Methotrexate toxicities with concomitant use of PPIs

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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