Zilon 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.52 (4 x 6: ৳ 180.48)
Strip Price: ৳ 45.12

Medicine Details

Category Details
Generic Omeprazole
Company Radiant pharmaceuticals ltd
Also available as
Zilon 20 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated ulcers
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 40 mg daily for severe or recurrent cases
  • 8 weeks in gastric ulceration
  • Maintenance dose for recurrent duodenal ulcer: 20 mg once daily
  • 10-20 mg daily for prevention of relapse in duodenal ulcer
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on the preceding evening for prophylaxis of acid aspiration
  • 20-120 mg daily for Zollinger-Ellison syndrome

Administration

  • Omeprazole IV injection for intravenous administration only
  • Omeprazole IV infusion as an intravenous infusion
  • Omeprazole IV infusion given over a period of 20-30 minutes or more

Interaction

  • Decreased intragastric acidity affecting absorption of ketoconazole
  • Metabolism through cytochrome P450 affecting elimination of certain drugs
  • Plasma concentrations of Omeprazole and clarithromycin increased during concomitant administration

Contraindications

  • Known hypersensitivity to Omeprazole
  • Suspected gastric ulcer with possibility of malignancy

Side Effects

  • Skin rash, urticaria, pruritus
  • Photosensitivity, bullous eruption, erythema multiforme
  • Diarrhoea, headache
  • Constipation, nausea/vomiting, flatulence, abdominal pain
  • Paraesthesia, dizziness, light headedness, feeling faint
  • Dry mouth, stomatitis, candidiasis

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child observed
  • Consideration for use during pregnancy
  • No information available on passage into breast milk or neonate

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Zilon
  • Association of PPI therapy with increased risk for osteoporosis-related fractures

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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