Esogap 40 mg (Tablet (Enteric Coated))

Unit Price: ৳ 8.00 (5 x 10: ৳ 400.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Esomeprazole
Company Euro pharma ltd
Also available as
Esogap 20 mg tablet Esogap 20 mg capsule Esogap 40 mg capsule Esogap 40 mg injection

Title

Esogap 40 mg Tablet

Categories

  • Medicine
  • Healthcare
  • Gastroenterology

Description

Esomeprazole is a proton pump inhibitor used to relieve chronic heartburn and other symptoms associated with GERD, heal erosive esophagitis, maintain healing of erosive esophagitis, eradicate Helicobacter pylori infection, treat Zollinger-Ellison Syndrome, acid-related dyspepsia, duodenal & gastric ulcers.

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Treatment of acid-related dyspepsia
  • Treatment of duodenal & gastric ulcers

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation for peak plasma levels

Absorption

  • Peak plasma levels occur at approximately 1.5 hours
  • Cmax increases proportionally with the dose

Distribution

  • 97% bound to plasma proteins
  • Steady-state apparent volume of distribution is approximately 16 L

Metabolism

  • Extensively metabolized in the liver by CYP enzymes
  • Metabolites lack anti-secretory activity

Excretion

  • Plasma elimination half-life of approximately 1-1.5 hours
  • Less than 1% excreted in the urine

Dosage

  • Oral and IV dosage forms available
  • Dosage varies for different indications and patient groups

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral suspension and IV injection instructions provided

Interactions

  • Extensively metabolized by CYP2C19 and CYP3A4
  • Potential interactions with diazepam and drugs affected by gastric pH

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Flatulence
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Excretion in milk not studied
  • Breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Instructions for patients to take capsules with applesauce provided
  • Antacids may be used concurrently

Use in Special Populations

  • Safety and efficacy not established in pediatric patients
  • No overall differences observed between elderly and younger individuals

Overdose Effects

  • Lethal to rats at high doses
  • Symptomatic and supportive treatment recommended

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: Image provided in the description

Commonly Asked Questions

  • Uses of Esogap 40 mg Tablet
  • Side effects of Esogap 40 mg Tablet
  • Information on pregnancy and breastfeeding
  • Onset of action of Esogap 40 mg Tablet
  • Quick tips for using Esogap 40 mg Tablet

Related Brands