Esomep 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 7.02 (5 x 10: ৳ 351.00)
Strip Price: ৳ 70.20
Medicine Details
| Category | Details |
|---|---|
| Generic | Esomeprazole |
| Company | Aci limited |
| Also available as |
Indications
- Relief from chronic heartburn symptoms
- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
- Treatment of Zollinger-Ellison Syndrome
- Treatment of acid-related Dyspepsia
- Treatment of duodenal and gastric ulcers
Pharmacology
- Proton pump inhibitor
- Suppression of gastric acid secretion
- Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
- Better acid control than racemic proton pump inhibitors
- Enteric-coated pellet formulation
- Peak plasma levels occur at approximately 1.5 hours after oral administration
- Extensive metabolism in the liver by the cytochrome P450 (CYP) enzyme system
- Plasma elimination half-life of approximately 1-1.5 hours
- Combination therapy with antimicrobials
Dosage
- Oral dosage form
- Different dosages for various conditions
- IV injection or IV infusion for specific patient groups
Administration
- Tablet or capsule to be swallowed whole one hour before a meal
- Oral suspension with specific instructions for preparation and administration
- IV injection preparation and administration
- Requirement of administering at least one hour before meals
Interaction
- Metabolized in the liver by CYP2C19 and CYP3A4
- Unlikely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
- Potential interference with the absorption of certain drugs
- Co-administration of oral contraceptives, diazepam, phenytoin, or quinidine
Contraindications
- Known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- No teratogenic effects in animal studies
- Excretion in milk not studied
- Discontinuation of breastfeeding if essential
Precautions & Warnings
- Symptomatic response does not preclude the presence of gastric malignancy
- Specific instructions for patients with difficulty swallowing capsules
- Use of antacids while taking Esomep
- Elderly and paediatric use considerations
- No dosage adjustment recommended for mild to moderate hepatic insufficiency
Use in Special Populations
- Safety and effectiveness not established in paediatric patients
- No overall differences in safety and efficacy observed between the elderly and younger individuals
- No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
- Expected unaltered pharmacokinetics in patients with renal impairment
Overdose Effects
- Signs of acute toxicity in animal studies
- No specific antidote known
- Symptomatic and supportive treatment recommended
- Consideration of multiple drug ingestion
Storage Conditions
- Temperature not exceeding 30°C
- Dry place
- Protection from light and moisture
- Keep out of reach of children
Chemical Structure
- Molecular formula: C17H19N3O3S
- Chemical structure image available
Common Questions
- Overview of Esomep 20 mg Capsule
- Multiple uses of the capsule
- Common side effects
- Considerations for pregnancy and breastfeeding
- Onset of action after administration
- Quick tips for usage