Esonix 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 11.00 (5 x 10: ৳ 550.00)
Strip Price: ৳ 110.00

Medicine Details

Category Details
Generic Esomeprazole
Company Incepta pharmaceuticals ltd
Also available as
Esonix 20 mg tablet Esonix 40 mg tablet Esonix 20 mg capsule Esonix 40 mg injection Esonix 20 mg powder Esonix 20 mg injection

Indications

  • Relief from chronic heartburn symptoms
  • Relief from symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment for Zollinger-Ellison Syndrome
  • Treatment for Acid-related Dyspepsia
  • Treatment for Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Inhibits H+/K+-ATPase
  • Provides better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation of esomeprazole magnesium
  • Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Plasma elimination half-life of approximately 1–1.5 hours

Dosage

  • Oral dosage form
  • Dosage varies for different indications
  • 20 mg or 40 mg once daily for healing of erosive esophagitis
  • 20 mg once daily for maintenance of healing of erosive esophagitis
  • 20 mg once daily for symptomatic GERD
  • Triple Therapy for Helicobacter pylori eradication
  • Dose varies for Zollinger-Ellison Syndrome, Acid-related Dyspepsia, Duodenal & Gastric ulcer
  • IV injection or IV infusion for certain indications

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Specific instructions for oral suspension administration
  • Preparation of solution for IV injection
  • Recommendation for administration through a nasogastric or gastric tube

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically relevant interactions with certain CYP enzymes
  • Potential interference with the absorption of certain drugs
  • Clinically significant interactions with specific drugs

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Specific instructions for patients with difficulty swallowing capsules
  • Advice regarding the use of antacids

Use in Special Populations

  • Safety and effectiveness in paediatric patients have not been established
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Toxic effects observed in animal studies at high doses
  • No specific antidote known
  • Symptomatic and supportive treatment recommended

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Image of chemical structure provided

Common Questions about Esonix 40 mg Capsule

  • Description of Esonix 40 mg Capsule as a proton pump inhibitor (PPI)
  • Multiple uses of Esonix 40 mg Capsule
  • Common side effects of Esonix 40 mg Capsule
  • Recommendation for pregnant or breastfeeding individuals
  • Duration of time for Esonix 40 mg Capsule to work
  • Quick tips for using Esonix 40 mg Capsule

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