Maxpro 40 mg/vial (IV Injection)

40 mg vial: ৳ 105.00

Medicine Details

Category Details
Generic Esomeprazole
Company Renata limited
Also available as
Maxpro 20 mg tablet Maxpro 40 mg tablet Maxpro 20 mg capsule Maxpro 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Zollinger-Ellison Syndrome treatment
  • Treatment of acid-related Dyspepsia
  • Treatment of Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Inhibition of the H+/K+-ATPase
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation
  • Extensively metabolized in the liver
  • Cytochrome P450 (CYP) enzyme system dependent metabolism
  • Plasma elimination half-life of approximately 1-1.5 hours

Dosage

  • Oral dosage form
  • IV Injection or IV infusion
  • Variety of doses based on indication and patient age/weight
  • Specific dosages for different indications such as zollinger-ellison syndrome and Helicobacter pylori eradication

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral suspension should be taken with specific instructions on mixing and administration
  • IV Injection solution for injection preparation

Interaction

  • Metabolized by CYP2C19 and CYP3A4
  • Potential interference with CYP2C19
  • No clinically significant interactions with specific drugs
  • Inhibition of gastric acid secretion

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth
  • No difference in types of related adverse events seen during maintenance treatment

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies revealed no teratogenic effects
  • Excretion of esomeprazole in milk has not been studied

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Specific guidance for patients who have difficulty swallowing capsules

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Lethal at high doses in animal studies
  • Reduced motor activity, changes in respiratory frequency, tremor, and convulsions

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

Common Questions about Maxpro 40 mg/vial Injection

  • Use as a proton pump inhibitor to reduce stomach acid production
  • Treatment for gastroesophageal reflux disease (GERD), ulcers, and other conditions related to excess stomach acid
  • Common side effects include headaches, diarrhea, nausea, and abdominal discomfort
  • Safety considerations for pregnant or breastfeeding women
  • Quick tips for medication use and potential side effects

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