Inpro 40 mg/vial (IV Injection)

40 mg vial: ৳ 70.00

Medicine Details

Category	Details
Generic	Omeprazole
Company	Biopharma limited
Also available as	Inpro 20 mg capsule Inpro 40 mg capsule

Indications

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Long-term management of acid reflux disease
Acid-related dyspepsia
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

Pharmacology

Inhibitor of gastric acid secretion by blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell

Dosage

20 mg once daily for benign gastric and duodenal ulcer
10-20 mg once daily for acid-related dyspepsia
40 mg preceding evening for prophylaxis of acid aspiration
20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
10-40 mg once daily for paediatric severe ulcerating reflux esophagitis
40 mg IV injection for prophylaxis of acid aspiration
60 mg IV for Zollinger-Ellison syndrome
40 mg IV for duodenal ulcer, gastric ulcer, or reflux oesophagitis

Administration

IV Injection for prophylaxis
IV Injection for duodenal and gastric ulcer
IV Injection for Zollinger-Ellison syndrome
IV Infusion over 20-30 minutes
IV Infusion over 100 ml saline or 5% Dextrose

Interaction

Decreased intragastric acidity may reduce absorption of ketoconazole, metabolized in the liver through cytochrome P450, may delay elimination of diazepam, phenytoin, and warfarin

Contraindications

Known hypersensitivity to omeprazole, suspicion of malignancy in gastric ulcer

Side Effects

Skin rash, urticaria, pruritus
Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
Diarrhoea, headache
Constipation, nausea/vomiting, flatulence, abdominal pain
Dry mouth, stomatitis, candidiasis
Paraesthesia, dizziness, lightheadedness, feeling faint
Somnolence, insomnia, vertigo
Reversible mental confusion, agitation, depression, hallucinations
Arthritic and myalgic symptoms
Blurred vision, taste disturbance, peripheral oedema
Increased sweating, gynaecomastia
Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia
Anaphylactic shock, malaise, fever
Bronchospasm, encephalopathy, hepatitis, hepatic failure
Increases in liver enzymes

Pregnancy & Lactation

Safe for pregnancy, discontinuation advised for breastfeeding, not established for pediatric patients below 18 years

Precautions & Warnings

Avoid concomitant use of clopidogrel and omeprazole
Increased risk of osteoporosis-related fractures with PPI therapy
Atrophic gastritis in patients treated long-term
Concomitant use with methotrexate may lead to toxicities

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat, out of the reach of children