Lomesec 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 3.00 (6 x 10: ৳ 180.00)
Strip Price: ৳ 30.00

Medicine Details

Category Details
Generic Omeprazole
Company Aexim pharmaceuticals ltd

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

Omeprazole, a substituted benzimidazole, is an inhibitor of gastric acid secretion. It inhibits gastric acid secretion by blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell. Onset of the antisecretory effect occurs within one hour, with the maximum effect occurring within two hours and inhibition of secretion lasts up to 72 hours. When discontinued, secretory activity returns gradually over 3 to 5 days.

Dosage

  • Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration
  • NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks, continued for further 4 weeks if not fully healed
  • Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks, continued for further 4-8 weeks if not fully healed
  • Long-term management of acid reflux disease: 10-20 mg daily
  • Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks
  • Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery
  • Zollinger-Ellison syndrome: Initially 60 mg once daily; usual range 20-120 mg daily
  • Helicobacter pylori eradication regimen in peptic ulcer disease: Omeprazole is recommended at a dose of 20 mg twice daily in association with antimicrobial agents

Administration

  • Direction for use of IV Injection: Omeprazole lyophilized powder and water for injection is for intravenous administration only and must not be given by any other route
  • Direction for use of IV Infusion: Omeprazole IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more
  • The reconstituted solution should not be mixed or co-administered in the same infusion set with any other drug

Interaction

Omeprazole can interact with ketoconazole, diazepam, phenytoin, warfarin, clarithromycin, digoxin, and others. It can affect the absorption and metabolism of these drugs, and monitoring and dose adjustments may be necessary.

Contraindications

Omeprazole is contraindicated in patients with known hypersensitivity to it. It should not be used if gastric ulcer is suspected and the possibility of malignancy should be excluded.

Side Effects

  • Skin rash, urticaria and pruritus
  • Photosensitivity, bullous eruption, erythema multiforme, angioedema and alopecia
  • Diarrhoea, headache, constipation, nausea/vomiting, flatulence and abdominal pain
  • Dry mouth, stomatitis and candidiasis
  • Paraesthesia, dizziness, light headedness and feeling faint
  • Somnolence, insomnia and vertigo
  • Mental confusion, agitation, depression and hallucinations
  • Arthritic and myalgic symptoms, blurred vision, taste disturbance, peripheral oedema, increased sweating, gynaecomastia
  • Leucopenia, thrombocytopenia, anaphylactic shock, malaise, fever, bronchospasm, encephalopathy, hepatitis, interstitial nephritis, hepatic failure, increases in liver enzymes

Pregnancy & Lactation

Omeprazole has shown no adverse effects on pregnancy, and it can be used during pregnancy. However, information on its passage into breast milk is unavailable, so breastfeeding should be discontinued if essential.

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Omeprazole
  • PPI therapy may be associated with an increased risk for osteoporosis-related fractures
  • Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with Omeprazole
  • Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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