Losectil 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 9.00 (6 x 10: ৳ 540.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Omeprazole
Company Eskayef pharmaceuticals ltd
Also available as
Losectil 20 mg capsule Losectil 10 mg capsule Losectil 20 mg powder Losectil 40 mg powder Losectil 40 mg injection Losectil v 20 mg capsule Losectil v 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated ulcers
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • Dosage for benign gastric and duodenal ulcer
  • Dosage for NSAID-associated duodenal or gastric ulcer
  • Dosage for gastro-esophageal reflux disease
  • Dosage for long-term management of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Dosage for Helicobacter pylori eradication regimen
  • Pediatric use in severe ulcerating reflux esophagitis

Administration

  • IV Injection direction
  • IV Infusion direction
  • Directions for reconstituting and administering IV injection
  • Directions for reconstituting and administering IV infusion

Interaction

  • Effect on absorption of ketoconazole
  • Metabolism through cytochrome P450
  • Interaction with diazepam, phenytoin, and warfarin
  • Plasma concentrations of Losectil and clarithromycin during concomitant administration
  • Effect on absorption of phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, antacids, piroxicam, diclofenac, naproxen, digoxin

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspicion of gastric ulcer with possibility of malignancy

Side Effects

  • Skin rash, urticaria, pruritus
  • Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
  • Diarrhoea, headache
  • Constipation, nausea/vomiting, flatulence, abdominal pain
  • Dry mouth, stomatitis, candidiasis
  • Paraesthesia
  • Dizziness, light headedness, feeling faint
  • Somnolence, insomnia, vertigo
  • Mental confusion, agitation, depression, hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral edema
  • Increased sweating, gynaecomastia, leucopenia, thrombocytopenia
  • Agranulocytosis, pancytopenia, anaphylactic shock
  • Malaise, fever, bronchospasm
  • Encephalopathy in patients with pre-existing severe liver disease, hepatitis, interstitial nephritis, hepatic failure
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child
  • No information on passage into breast milk or effects on neonate
  • Discontinuation of breastfeeding if essential

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Associations with increased risk for osteoporosis-related fractures
  • Atrophic gastritis in patients treated long-term
  • Concomitant use with methotrexate

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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