Omepra 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.02 (3 x 10: ৳ 210.60)
Strip Price: ৳ 70.20

Medicine Details

Category Details
Generic Omeprazole
Company Alco pharma ltd
Also available as

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocker of hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of anti-secretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer for 4 weeks in duodenal ulceration and 8 weeks in gastric ulceration
  • 40 mg daily in severe or recurrent cases of gastric and duodenal ulcer
  • 10-20 mg daily for prevention of relapse in duodenal ulcer
  • 20 mg once daily for NSAID-associated duodenal or gastric ulcer for 4 weeks, continued for further 4 weeks if not fully healed
  • 20 mg once daily for 4 weeks in Gastro-esophageal reflux disease, continued for further 4-8 weeks if not fully healed
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for 2-4 weeks for acid-related dyspepsia
  • 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
  • 20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
  • 10-40 mg once daily for severe ulcerating reflux esophagitis based on body weight (Child>1 year)

Administration

  • Omeprazole IV injection for intravenous administration only
  • Omeprazole IV infusion as an intravenous infusion over a period of 20-30 minutes or more
  • Use only freshly prepared solution
  • IV injection given as a slow intravenous injection over a period of at least 2 to 5 minutes at a maximum rate of 4 ml/minute
  • Dissolve in saline for infusion or 5% Dextrose for infusion
  • Reconstituted solution should not be mixed or co-administered with any other drug

Interaction

  • Decreased intragastric acidity may reduce the absorption of ketoconazole
  • Metabolized in the liver through cytochrome P450
  • May delay the elimination of diazepam, phenytoin, and warfarin
  • Monitoring of patients receiving warfarin or phenytoin is recommended
  • Concomitant treatment with Omeprazole 20mg daily did not change the blood concentration of phenytoin in patients on continuous treatment
  • Plasma concentrations of Omeprazole and clarithromycin are increased during concomitant administration
  • Absorption of Omeprazole is not affected by alcohol or food

Contraindications

  • Known hypersensitivity to Omeprazole
  • Suspicion of gastric ulcer with possibility of malignancy

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhoea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dizziness, light-headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, and peripheral edema
  • Increased sweating, gynaecomastia, leucopenia, thrombocytopenia, and agranulocytosis
  • Malaise, fever, bronchospasm, and encephalopathy

Pregnancy & Lactation

  • Omeprazole can be used during pregnancy
  • No information available on the passage of Omeprazole into breast milk

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Omeprazole
  • May be associated with an increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in long-term treated patients
  • Concomitant use with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat

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