Omepra 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 7.02 (3 x 10: ৳ 210.60)
Strip Price: ৳ 70.20
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Alco pharma ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocker of hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of anti-secretory effect within one hour
- Maximum effect occurring within two hours
- Inhibition of secretion lasts up to 72 hours
Dosage
- 20 mg once daily for benign gastric and duodenal ulcer for 4 weeks in duodenal ulceration and 8 weeks in gastric ulceration
- 40 mg daily in severe or recurrent cases of gastric and duodenal ulcer
- 10-20 mg daily for prevention of relapse in duodenal ulcer
- 20 mg once daily for NSAID-associated duodenal or gastric ulcer for 4 weeks, continued for further 4 weeks if not fully healed
- 20 mg once daily for 4 weeks in Gastro-esophageal reflux disease, continued for further 4-8 weeks if not fully healed
- 10-20 mg daily for long-term management of acid reflux disease
- 10-20 mg once daily for 2-4 weeks for acid-related dyspepsia
- 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
- 20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
- 10-40 mg once daily for severe ulcerating reflux esophagitis based on body weight (Child>1 year)
Administration
- Omeprazole IV injection for intravenous administration only
- Omeprazole IV infusion as an intravenous infusion over a period of 20-30 minutes or more
- Use only freshly prepared solution
- IV injection given as a slow intravenous injection over a period of at least 2 to 5 minutes at a maximum rate of 4 ml/minute
- Dissolve in saline for infusion or 5% Dextrose for infusion
- Reconstituted solution should not be mixed or co-administered with any other drug
Interaction
- Decreased intragastric acidity may reduce the absorption of ketoconazole
- Metabolized in the liver through cytochrome P450
- May delay the elimination of diazepam, phenytoin, and warfarin
- Monitoring of patients receiving warfarin or phenytoin is recommended
- Concomitant treatment with Omeprazole 20mg daily did not change the blood concentration of phenytoin in patients on continuous treatment
- Plasma concentrations of Omeprazole and clarithromycin are increased during concomitant administration
- Absorption of Omeprazole is not affected by alcohol or food
Contraindications
- Known hypersensitivity to Omeprazole
- Suspicion of gastric ulcer with possibility of malignancy
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme
- Diarrhoea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
- Dizziness, light-headedness, and feeling faint
- Somnolence, insomnia, and vertigo
- Reversible mental confusion, agitation, depression, and hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, and peripheral edema
- Increased sweating, gynaecomastia, leucopenia, thrombocytopenia, and agranulocytosis
- Malaise, fever, bronchospasm, and encephalopathy
Pregnancy & Lactation
- Omeprazole can be used during pregnancy
- No information available on the passage of Omeprazole into breast milk
Precautions & Warnings
- Avoid concomitant use of clopidogrel and Omeprazole
- May be associated with an increased risk for osteoporosis-related fractures
- Atrophic gastritis noted occasionally in long-term treated patients
- Concomitant use with methotrexate may lead to methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
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