Omeprol 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (5 x 8: ৳ 280.00)

Strip Price: ৳ 56.00

Medicine Details

Category	Details
Generic	Omeprazole
Company	Ziska pharmaceuticals ltd
Also available as	Omeprol 20 mg capsule Omeprol 40 mg injection

Indications

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Acid-related dyspepsia
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

Pharmacology

Inhibitor of gastric acid secretion, blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system, onset of antisecretory effect occurs within one hour, maximum effect within two hours, inhibition of secretion lasts up to 72 hours

Dosage

20 mg once daily for 4 weeks in duodenal ulceration
40 mg once daily in severe or recurrent cases
10-20 mg daily for prevention of relapse in duodenal ulcer
20 mg once daily for 4-8 weeks in Gastro-esophageal reflux disease
Maintenance dose of 20 mg once daily
10-20 mg daily for long-term management of acid reflux disease
40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
Recommended dose of 20 mg twice daily in Helicobacter pylori eradication regimen

Administration

IV Injection given slowly over a period of 5 minutes
IV Infusion over a period of 20-30 minutes or more
Solution for IV infusion should be used within 12 hours when dissolved in saline and within 6 hours when dissolved in 5% Dextrose

Interaction

Decreased intragastric acidity may reduce the absorption of ketoconazole
Metabolised in the liver through cytochrome P450, can delay the elimination of various drugs
Plasma concentrations of Omeprazole and clarithromycin are increased during concomitant administration

Contraindications

Contraindicated in patients with known hypersensitivity to it

Side Effects

Skin rash, urticaria, and pruritus
Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
Diarrhoea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
Dry mouth, stomatitis, and candidiasis
Dizziness, light-headedness, and feeling faint
Somnolence, insomnia, and vertigo
Reversible mental confusion, agitation, depression, and hallucinations
Arthritic and myalgic symptoms
Thrombocytopenia, anaphylactic shock, malaise, fever, bronchospasm, and hepatic failure

Pregnancy & Lactation

Results from three prospective epidemiological studies indicate no adverse effects on pregnancy or on the health of the fetus/newborn child. Use in children & adolescents under 18 years not established

Precautions & Warnings

Avoid concomitant use with clopidogrel
Observational studies suggest an increased risk for osteoporosis-related fractures
Atrophic gastritis noted occasionally in long-term treatment
Concomitant use with methotrexate may lead to toxicities