PPI 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.01 (10 x 14: ৳ 701.40)
Strip Price: ৳ 70.14

Medicine Details

Category Details
Generic Omeprazole
Company Acme laboratories ltd
Also available as
Ppi 40 mg capsule Ppi 40 mg injection

Indications

  • Treatment of Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Substituted benzimidazole
  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days after discontinuation
  • Oral administration
  • IV Injection

Dosage

  • Doses for different indications (e.g., benign gastric and duodenal ulcer, NSAID-associated duodenal or gastric ulcer, gastro-esophageal reflux disease, long-term management of acid reflux disease, acid-related dyspepsia, prophylaxis of acid aspiration, Zollinger-Ellison syndrome, Helicobacter pylori eradication regimen, pediatric use)
  • Oral administration instructions
  • IV Injection administration instructions

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion
  • Intravenous administration only
  • Must not be given by any other route
  • Intravenous infusion over a period of 20-30 minutes or more
  • Preparation and usage instructions for IV infusion

Interaction

  • Potential drug interactions with ketoconazole, diazepam, phenytoin, warfarin, clarithromycin, amoxicillin, metronidazole, piroxicam, diclofenac, naproxen, digoxin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, phenacetin, and antacids
  • No evidence of interaction with alcohol or food

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspicion of gastric ulcer

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
  • Diarrhea, headache, constipation, nausea/vomiting, flatulence, abdominal pain
  • Dry mouth, stomatitis, candidiasis
  • Paraesthesia, dizziness, light headedness, feeling faint, somnolence, insomnia, vertigo
  • Reversible mental confusion, agitation, depression, hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral edema, increased sweating, gynaecomastia
  • Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever
  • Bronchospasm, encephalopathy, hepatitis, interstitial nephritis, hepatic failure
  • Increase in liver enzymes

Pregnancy & Lactation

  • No adverse effects on pregnancy or on the health of the fetus/newborn child based on epidemiological studies
  • Safe for use during pregnancy
  • No information on passage into breast milk or effects on the neonate
  • Discontinuation of breastfeeding if essential

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Potential risk of osteoporosis-related fractures
  • Atrophic gastritis noted in long-term treatment
  • Potential methotrexate toxicities with concomitant use

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place
  • Away from light and heat
  • Keep out of the reach of children

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