PPI 40 mg/vial (IV Injection)

40 mg vial: ৳ 90.00

Medicine Details

Category Details
Generic Omeprazole
Company Acme laboratories ltd
Also available as
Ppi 20 mg capsule Ppi 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with history of NSAID-associated ulcers
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days upon discontinuation

Dosage

  • Different dosage for different indications
  • Oral and IV administration options
  • Varied dosing based on patient's condition and age
  • Recommendations for maintenance doses and prevention of relapse

Administration

  • Directions for use of IV Injection and IV Infusion
  • Recommendations for reconstitution and dilution
  • Instructions on maximum rate of administration
  • Limited shelf life after reconstitution

Interaction

  • Impact on absorption of ketoconazole
  • Metabolism through cytochrome P450 affecting diazepam, phenytoin, and warfarin
  • Monitoring and potential dose adjustments for warfarin and phenytoin
  • Data on concomitant treatment with various drugs

Contraindications

  • Known hypersensitivity to omeprazole
  • Exclusion of malignancy before treatment

Side Effects

  • Mild and reversible adverse reactions
  • Reports of skin rash, urticaria, and pruritus
  • Cases of photosensitivity, bullous eruption, and alopecia
  • Gastrointestinal reactions including diarrhea, headache, and more

Pregnancy & Lactation

  • Results from prospective epidemiological studies
  • Use of omeprazole during pregnancy
  • Limited information on breastfeeding, with recommendation to discontinue if essential

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and PPI
  • Potential association with increased risk for osteoporosis-related fractures
  • Observations of atrophic gastritis in long-term use cases
  • Caution with concomitant use of PPIs and methotrexate

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Instructions for storage in a dry place away from light and heat
  • Advisory to keep out of the reach of children

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