Prevencid 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.02 (10 x 10: ৳ 502.00)
Strip Price: ৳ 50.20

Medicine Details

Category Details
Generic Omeprazole
Company Rangs pharmaceuticals ltd
Also available as
Omag dr 20 mg tablet Prevencid 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg once daily for 4 weeks in duodenal ulceration
  • 8 weeks in gastric ulceration
  • In severe or recurrent cases, dose to be increased to 40 mg daily
  • Maintenance dose for recurrent duodenal ulcer, 20 mg once daily
  • 20 mg once daily for 4 weeks in NSAID-associated duodenal or gastric ulcer
  • In prevention of relapse in duodenal ulcer, 10-20 mg daily
  • 20 mg once daily for 4 weeks in gastro-esophageal reflux disease
  • 40 mg once daily for 8 weeks in gastro-esophageal reflux disease, refractory to other treatment
  • Maintenance dose is 20 mg once daily
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for 2-4 weeks in acid-related dyspepsia
  • 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
  • Initially 60 mg once daily for zollinger-Ellison syndrome
  • Recommended dose of 20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
  • For paediatric use in severe ulcerating reflux esophagitis: 10-40 mg once daily depending on body weight

Administration

  • IV Injection should be given slowly over a period of 5 minutes
  • IV Infusion should be given over a period of 20-30 minutes or more
  • The solution for IV injection should be used within 4 hours of reconstitution

Interaction

  • Decreased intragastric acidity may reduce the absorption of ketoconazole during treatment
  • Metabolized in the liver through cytochrome P450
  • Can delay the elimination of diazepam, phenytoin, and warfarin
  • Monitoring of patients receiving warfarin or phenytoin is recommended
  • Concomitant treatment with Prevencid 20mg daily did not change the blood concentration of phenytoin in patients

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspicion of gastric ulcer should exclude the possibility of malignancy before treatment

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhea and headache
  • Constipation, nausea/vomiting, and flatulence
  • Dry mouth, stomatitis, and candidiasis
  • Paraesthesia
  • Dizziness, light headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision and taste disturbance
  • Peripheral edema and increased sweating
  • Hepatitis with or without jaundice, and interstitial nephritis

Pregnancy & Lactation

  • No adverse effects of omeprazole on pregnancy or the health of the fetus/newborn child indicated by epidemiological studies
  • Omeprazole can be used during pregnancy
  • No information available on the passage of omeprazole into breast milk or its effects on the neonate
  • Use in children and adolescents less than 18 years of age not established

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and omeprazole
  • Observational studies suggest increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in gastric corpus biopsies from patients treated long-term with omeprazole
  • Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Therapeutic Class

  • Proton Pump Inhibitor

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