Prevencid 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.03 (5 x 4: ৳ 160.60)
Strip Price: ৳ 32.12

Medicine Details

Category Details
Generic Omeprazole
Company Rangs pharmaceuticals ltd
Also available as
Omag dr 20 mg tablet Prevencid 20 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 40 mg once daily for severe or recurrent cases of gastric ulcer
  • 10-20 mg daily for preventing relapse in duodenal ulcer
  • 40 mg once daily for prophylaxis of acid aspiration
  • Initial 60 mg once daily for Zollinger-Ellison syndrome
  • 20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
  • 10-20 mg once daily for severe ulcerating reflux esophagitis (Child>1 year)

Administration

  • IV Injection for prophylaxis of acid aspiration
  • IV Infusion over a period of 20-30 minutes or more

Interaction

  • Decreased intragastric acidity affecting the absorption of ketoconazole
  • Metabolized in the liver through cytochrome P450
  • Plasma concentrations increased during concomitant administration with clarithromycin
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, or antacids
  • Absorption not affected by alcohol or food

Contraindications

  • Known hypersensitivity

Side Effects

  • Skin rash, urticaria, pruritus
  • Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
  • Diarrhoea, headache, constipation, nausea/vomiting
  • Dry mouth, stomatitis, candidiasis
  • Paraesthesia, dizziness, light headedness
  • Somnolence, insomnia, vertigo
  • Reversible mental confusion, agitation, depression, hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral edema
  • Increased sweating, gynaecomastia, leucopenia
  • Thrombocytopenia, agranulocytosis, pancytopenia
  • Anaphylactic shock, malaise, fever
  • Bronchospasm, encephalopathy, hepatitis with or without jaundice
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects on pregnancy or on the health of the fetus/newborn child
  • No information available on the passage into breast milk

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Prevencid
  • Increased risk for osteoporosis-related fractures with PPI therapy
  • Atrophic gastritis noted in patients treated long-term with Prevencid
  • Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Dry place away from light and heat
  • Keep out of the reach of children

Related Brands