Esonix 40 mg/vial (IV Injection)

40 mg vial: ৳ 110.00

Medicine Details

Category Details
Generic Esomeprazole
Company Incepta pharmaceuticals ltd
Also available as
Esonix 20 mg tablet Esonix 40 mg tablet Esonix 20 mg capsule Esonix 40 mg capsule Esonix 20 mg powder Esonix 20 mg injection

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease in combination with amoxicillin and clarithromycin
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Inhibits gastric acid secretion
  • Formulated with enteric-coated pellets
  • Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Metabolized in the liver by cytochrome P450 enzyme system

Dosage

  • Healing of erosive esophagitis: 20 mg or 40 mg once daily for 4-8 weeks
  • Symptomatic GERD: 20 mg once daily for 4 weeks
  • Maintenance of Healing of Erosive Esophagitis: 20 mg once daily
  • Helicobacter Pylori eradication: Triple Therapy for 10 days
  • Zollinger-Ellison Syndrome: 20-80 mg once daily
  • Acid-related Dyspepsia: 20-40 mg once daily for 2-4 weeks
  • Duodenal ulcer: 20 mg once daily for 2-4 weeks, Gastric ulcer: 20-40 mg once daily for 4-8 weeks
  • IV Injection or IV infusion for various conditions based on patient age and weight

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Proper administration of oral suspension
  • Preparation of IV Injection solution
  • Use of antacids while taking the product

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Unlikely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
  • Potential interference with the absorption of drugs where gastric pH is important
  • Effects of combination therapy with clarithromycin

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects in animal studies
  • Excretion in milk not studied, breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Guidelines for patients with difficulty swallowing capsules

Use in Special Populations

  • Safety and effectiveness not established in paediatric patients
  • No overall differences in safety and efficacy in the elderly
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Lethal dose in rats
  • Signs of acute toxicity include reduced motor activity, changes in respiratory frequency, tremor, ataxia, and convulsions
  • No specific antidote known, treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image: Available

Commonly Asked Questions

  • Information about Esonix 40 mg/vial Injection
  • Uses, side effects, pregnancy/breastfeeding, time to work, and quick tips

Compound Summary

Please refer to the 'Chemical Structure' attribute for details.

Related Brands