Losectil 10 mg (Capsule (Enteric Coated))

Unit Price: ৳ 3.00 (12 x 10: ৳ 360.00)
Strip Price: ৳ 30.00

Medicine Details

Category Details
Generic Omeprazole
Company Eskayef pharmaceuticals ltd
Also available as
Losectil 20 mg capsule Losectil 40 mg capsule Losectil 20 mg powder Losectil 40 mg powder Losectil 40 mg injection Losectil v 20 mg capsule Losectil v 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 20 mg once daily for NSAID-associated duodenal or gastric ulcer
  • 20 mg once daily for gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on the preceding evening for prophylaxis of acid aspiration
  • 60 mg once daily for Zollinger-Ellison syndrome
  • 20 mg twice daily for Helicobacter pylori eradication regimen
  • 10-20 mg once daily for severe ulcerating reflux esophagitis (Child>1 year)
  • 40 mg as intravenous injection for prophylaxis of acid aspiration
  • 40 mg intravenously for duodenal ulcer, gastric ulcer or reflux esophagitis
  • 60 mg daily for Zollinger-Ellison syndrome (intravenous)

Administration

  • Omeprazole IV injection for intravenous administration only
  • Omeprazole IV injection given as a slow intravenous injection
  • Omeprazole IV infusion given as intravenous infusion over a period of 20-30 minutes or more

Interaction

  • Decreased intragastric acidity affecting absorption of ketoconazole
  • Metabolized in the liver through cytochrome P450
  • Possible delay in elimination of diazepam, phenytoin, and warfarin
  • Increased plasma concentrations during concomitant administration with clarithromycin
  • No evidence of interaction with phenacetin, theophylline, caffeine, and more

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspected gastric ulcer with possibility of malignancy

Side Effects

  • Well tolerated with generally mild and reversible adverse reactions
  • Reported cases of skin rash, urticaria, pruritus, photosensitivity, and more

Pregnancy & Lactation

  • No adverse effects reported on pregnancy or newborn child
  • Use during pregnancy considered safe
  • No information available on passage into breast milk
  • Discontinuation of breast-feeding if essential use is considered

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Possible association with increased risk of osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in long-term treatment
  • Risk of methotrexate toxicities with concomitant use

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Related Brands