Losectil 40 mg/sachet (Oral Powder)

40 mg sachet: ৳ 10.00 (30's pack: ৳ 300.00)

Medicine Details

Category Details
Generic Omeprazole
Company Eskayef pharmaceuticals ltd
Also available as
Losectil 20 mg capsule Losectil 10 mg capsule Losectil 40 mg capsule Losectil 20 mg powder Losectil 40 mg injection Losectil v 20 mg capsule Losectil v 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocker of hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasting up to 72 hours

Dosage

  • 20 mg once daily for 4-8 weeks in various conditions
  • 40 mg daily in severe or recurrent cases

Administration

  • For intravenous administration only
  • IV injection should be given slowly over a period of 5 minutes
  • IV infusion should be given over a period of 20-30 minutes or more

Interaction

  • Decreased intragastric acidity affecting the absorption of ketoconazole
  • Metabolism in the liver through cytochrome P450 affecting the elimination of diazepam, phenytoin, and warfarin
  • Concomitant treatment with other medications affecting plasma concentrations

Contraindications

  • Known hypersensitivity to the product

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Diarrhoea and headache
  • Gastrointestinal reactions including constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dizziness, light headedness, and feeling faint
  • Mental confusion, agitation, depression, and hallucinations

Pregnancy & Lactation

  • No adverse effects on pregnancy or on the health of the fetus/newborn child

Precautions & Warnings

  • Avoid concomitant use of clopidogrel
  • Increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in gastric corpus biopsies

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Dry place away from light and heat
  • Keep out of the reach of children

Related Brands