Losek 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 4.00 (60's pack: ৳ 240.00)

Medicine Details

Category Details
Generic Omeprazole
Company Bristol pharmaceuticals ltd
Also available as
Losek 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Inhibits gastric acid secretion by blocking H+/K+ ATPase enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days after discontinuation

Dosage

  • Dosage for benign gastric and duodenal ulcer
  • Dosage for NSAID-associated duodenal or gastric ulcer
  • Dosage for gastro-esophageal reflux disease
  • Dosage for long-term management of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Dosage for Helicobacter pylori eradication regimen in peptic ulcer disease
  • Paediatric use in severe ulcerating reflux esophagitis

Administration

  • IV Injection administration
  • IV Infusion administration
  • Direction for use of IV Injection
  • Direction for use of IV Infusion
  • Reconstitution of IV injection
  • Reconstitution of IV infusion
  • Instructions for slow intravenous injection
  • Maximum rate of IV injection
  • Freshly prepared solution required
  • Use within specified time after reconstitution
  • Instructions for intravenous infusion over a period of 20-30 minutes or more
  • Instructions for dissolved in saline or 5% Dextrose for infusion
  • Reconstituted solution should not be mixed or co-administered with any other drug

Interaction

  • Decreased intragastric acidity affecting absorption of ketoconazole
  • Metabolism in the liver through cytochrome P450
  • Possible delay in elimination of diazepam, phenytoin, and warfarin
  • Plasma concentrations of Omeprazole and clarithromycin
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, or antacids
  • No effect on absorption by alcohol or food
  • Increase in bioavailability of digoxin with simultaneous treatment

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspicion of gastric ulcer should exclude the possibility of malignancy before treatment

Side Effects

  • Skin rash, urticaria and pruritus
  • Photosensitivity and bullous eruption
  • Diarrhoea and headache
  • Constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Paraesthesia
  • Dizziness, light headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, and peripheral oedema
  • Increase in liver enzymes

Pregnancy & Lactation

  • No adverse effects of omeprazole on pregnancy or fetus/newborn child indicated by epidemiological studies
  • Use during pregnancy possible
  • No information available on passage into breast milk or effects on the neonate
  • Use of omeprazole essential warrants discontinuation of breastfeeding
  • Safety and effectiveness not established in pediatric patients less than 18 years of age

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and omeprazole
  • Increased risk for osteoporosis-related fractures with PPI therapy
  • Atrophic gastritis occasionally noted in long-term treatment with omeprazole
  • Concomitant use with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Dry place away from light and heat
  • Keep out of the reach of children

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