O-20 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (100's pack: ৳ 500.00)

Medicine Details

Category Details
Generic Omeprazole
Company Asiatic laboratories ltd
Also available as
O 40 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 20 mg once daily for NSAID-associated duodenal or gastric ulcer
  • 20 mg once daily for gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on the preceding evening for prophylaxis of acid aspiration
  • Initially 60 mg once daily for Zollinger-Ellison syndrome
  • Omeprazole 20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
  • 10-20 mg once daily for severe ulcerating reflux esophagitis (Child>1 year)

Administration

  • IV Injection: to be given slowly over a period of 5 minutes
  • IV Injection: recommended dose of 40 mg once daily for duodenal ulcer, gastric ulcer or reflux oesophagitis
  • IV Injection: initial dose of 60 mg daily for Zollinger-Ellison Syndrome
  • IV Infusion: to be given over a period of 20-30 minutes or more

Interaction

  • Decreases absorption of ketoconazole during treatment
  • Metabolized in the liver through cytochrome P450
  • May delay the elimination of diazepam, phenytoin and warfarin
  • Concomitant treatment with O-20 and clarithromycin increases plasma concentrations
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin or antacids

Contraindications

  • Known hypersensitivity to omeprazole
  • Possibility of malignancy when gastric ulcer is suspected

Side Effects

  • Skin rash, urticaria and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhoea and headache
  • Gastrointestinal reactions like constipation, nausea/vomiting, flatulence, and abdominal pain
  • Paraesthesia, dizziness, and light headedness
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, and peripheral oedema

Pregnancy & Lactation

  • No adverse effects on pregnancy or on the health of the fetus/newborn child
  • No information available on the passage of omeprazole into breast milk

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and O-20
  • Increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in gastric corpus biopsies from patients treated long-term
  • Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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