Losectil V 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Omeprazole
Company Eskayef pharmaceuticals ltd
Also available as
Losectil 20 mg capsule Losectil 10 mg capsule Losectil 40 mg capsule Losectil 20 mg powder Losectil 40 mg powder Losectil 40 mg injection Losectil v 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell
  • Onset of the antisecretory effect occurs within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days when the drug is discontinued

Dosage

  • Dosage for benign gastric and duodenal ulcer
  • Dosage for NSAID-associated duodenal or gastric ulcer
  • Dosage for gastro-esophageal reflux disease
  • Dosage for long-term management of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Dosage for Helicobacter pylori eradication regimen in peptic ulcer disease
  • Pediatric use in severe ulcerating reflux esophagitis

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion
  • Reconstitution instructions
  • Intravenous administration guidelines
  • Intravenous infusion duration

Interaction

  • Decreased intragastric acidity affecting absorption of other drugs
  • Metabolism through cytochrome P450 affecting drugs like diazepam, phenytoin, and warfarin
  • Monitoring and potential dose adjustment for warfarin or phenytoin
  • Plasma concentration changes during concomitant administration with clarithromycin
  • Absence of interaction with certain drugs like phenacetin, theophylline, caffeine, etc.
  • Effect on the absorption and bioavailability of digoxin

Contraindications

  • Hypersensitivity to omeprazole
  • Requirement to exclude malignancy before treatment for suspected gastric ulcer

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, erythema multiforme
  • Diarrhea and headache
  • Gastrointestinal reactions including constipation, nausea/vomiting, flatulence, and abdominal pain
  • Neurological reactions like paraesthesia, dizziness, and somnolence
  • Mental and emotional symptoms like confusion, agitation, depression, and hallucinations
  • Hematological and hepatic symptoms
  • Long-term effects on liver enzymes

Pregnancy & Lactation

  • Results from prospective studies indicating no adverse effects on pregnancy or fetus
  • Use during pregnancy based on available evidence
  • Lack of information on passage into breast milk
  • Discontinuation of breastfeeding if essential use of omeprazole

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Association with increased risk for osteoporosis-related fractures
  • Possible atrophic gastritis in long-term use
  • Potential for methotrexate toxicities with concomitant use

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Related Brands