Losectil V 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (10 x 6: ৳ 480.00)

Strip Price: ৳ 48.00

Medicine Details

Category	Details
Generic	Omeprazole
Company	Eskayef pharmaceuticals ltd
Also available as	Losectil 20 mg capsule Losectil 10 mg capsule Losectil 40 mg capsule Losectil 20 mg powder Losectil 40 mg powder Losectil 40 mg injection Losectil v 20 mg capsule

Indications

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Long-term management of acid reflux disease
Acid-related dyspepsia
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

Pharmacology

Inhibitor of gastric acid secretion, onset of antisecretory effect occurs within one hour, maximum effect occurring within two hours, inhibition of secretion lasts up to 72 hours

Dosage

20 mg once daily for benign gastric and duodenal ulcer treatment
40 mg once daily for severe or recurrent cases of benign gastric and duodenal ulcer
10-20 mg daily for long-term management of acid reflux disease
40 mg once daily for prophylaxis of acid aspiration

Administration

IV Injection for prophylaxis of acid aspiration
IV Infusion given over a period of 20-30 minutes or more
IV Injection should be given as a slow intravenous injection

Interaction

Decreased intragastric acidity affecting the absorption of ketoconazole
Metabolism in the liver through cytochrome P450 affecting the elimination of diazepam, phenytoin, and warfarin
Plasma concentrations increased during concomitant administration with clarithromycin

Contraindications

Known hypersensitivity to omeprazole, suspected gastric ulcer with possibility of malignancy

Side Effects

Skin rash, urticaria, and pruritus
Photosensitivity, bullous eruption, erythema multiforme
Diarrhea, headache, constipation, nausea/vomiting
Dry mouth, stomatitis, candidiasis
Dizziness, somnolence, insomnia
Reversible mental confusion, agitation, depression
Arthritic and myalgic symptoms
Increases in liver enzymes

Pregnancy & Lactation

No adverse effects on pregnancy or the health of the fetus/newborn child, use during pregnancy is considered safe, information not available on the passage into breast milk

Precautions & Warnings

Avoid concomitant use of clopidogrel and omeprazole
Increased risk for osteoporosis-related fractures
Atrophic gastritis noted occasionally in gastric corpus biopsies from long-term treatment
Concomitant use with methotrexate may lead to toxicities