Losectil 40 mg/vial (IV Injection)

40 mg vial: ৳ 90.00

Medicine Details

Category Details
Generic Omeprazole
Company Eskayef pharmaceuticals ltd
Also available as
Losectil 20 mg capsule Losectil 10 mg capsule Losectil 40 mg capsule Losectil 20 mg powder Losectil 40 mg powder Losectil v 20 mg capsule Losectil v 40 mg capsule

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer treatment
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease treatment
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia treatment
  • Severe ulcerating reflux esophagitis treatment
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome treatment
  • Helicobacter pylori-induced peptic ulcer treatment

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity after discontinuation

Dosage

  • Oral dosage for various conditions
  • IV injection dosage for prophylaxis of acid aspiration
  • IV injection dosage for duodenal ulcer, gastric ulcer, or reflux esophagitis

Administration

  • Instructions for IV injection use
  • Instructions for IV infusion use

Interaction

  • Decreased intragastric acidity affecting drug absorption
  • Metabolism through cytochrome P450
  • Effect on the absorption and elimination of other drugs

Contraindications

  • Known hypersensitivity to Omeprazole
  • Need to exclude possibility of malignancy before treatment

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, erythema multiforme
  • Diarrhoea, headache, constipation, nausea/vomiting
  • Dry mouth, stomatitis, candidiasis
  • Dizziness, somnolence, reversible mental confusion
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral oedema
  • Gynaecomastia, increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects of Omeprazole on pregnancy or fetus/child
  • Use during pregnancy considered safe
  • No information available on passage into breast milk or effects on neonate
  • Discontinuation of breastfeeding if essential

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Possible association with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted in long-term users
  • Potential for methotrexate toxicities with concomitant use

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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